Bone Marrow Concentrate (BMC)

Bone Marrow Concentrate (BMC)

BMC is an autologous product that is prepared from patients’ own bone-marrow aspirates. BMC composed of supernatant with platelets, hematopoietic stem cells (HSCs), small size mesenchymal stem cells (MSCs) and the RBCs with largest size (MSCs). Usually, the supernatant with platelets in the BMC, provides growth factors to support proliferation of cells within the body, and acts as scaffold for attaching cells to the site of damage and eventually prevents cell apoptosis and regulates tissue remodeling. While, cellular parts of the BMC provide the supply of stem cells to replenish the need of cells to regenerate the targeted tissues.

Conditions Treated

BMC is an autologous product that is prepared from patients’ own bone-marrow aspirates. BMC composed of supernatant with platelets, hematopoietic stem cells (HSCs), small size mesenchymal stem cells (MSCs) and the RBCs with largest size (MSCs). Usually, the supernatant with platelets in the BMC, provides growth factors to support proliferation of cells within the body, and acts as scaffold for attaching cells to the site of damage and eventually prevents cell apoptosis and regulates tissue remodeling. While, cellular parts of the BMC provide the supply of stem cells to replenish the need of cells to regenerate the targeted tissues.

Knee pain (advanced, Grade III-IV)
Shoulder pain
Hip pain
Elbow pain
Ankle pain
Back pain
Heel pain (plantar fasciitis)
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How Is Prepared

Preparation of BMC requires a small amount of patient’s bone marrow aspirate (50-100 ml or as per patients’ need). In TotiCell Ltd, patient specific (as per indications) PRP is produced using cGMP guidelines and then administered into the patients via an ultrasound guided intra-articular injection.
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Advice Before Treatment

Discontinue the use of NSAIDs 1 week before the procedure
Discontinue any blood thinning herbs, supplements, or vitamins 1 week before the procedure
Discontinue systemic use of corticosteroids 4 weeks before the procedure.
Have a healthy breakfast and drink plenty of water on the day of the procedure.
Avoid smoking
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Advice After Treatment

Avoid blood-thinning herbs, supplements, or vitamins for first 3 days post-procedure
Avoid caffeine an alcoholic beverage for the first week post-procedure.
Avoid anti-inflammatory medications for 2 weeks post-procedure
Avoid systematic steroids for 4 weeks post-procedure

Duration

The whole treatment process may require 2-3 hours and usually does not require any sort of rehabilitation afterward. Treatment modalities that are also relatively painless with fewer side effects compared to the surgery. However, few patients may suffer from slight discomfort. Pain relievers that do not target inflammation, such as Tylenol, can be used to relieve this discomfort. Patients are generally re-examined 2-6 weeks after the procedure(s) and usually within six weeks patients return to full activities.

FAQ

Question: What is stem cell treatment?

Stem cells have great potential as a treatment method for chronic diseases. Stem cell treatment uses two important properties of stem cells: they have self-renewal capability. And they have multi-differentiation potential. Stem cells are harvested from different sources of human body. They are useful for the maintenance of tissue as well as for repair after any degeneration or injury.

Question: What are the sources of stem cells?

Stem cells are harvested from different sources of human body such as bone marrow aspirate, adipose tissue, umbilical cord and blood. Depending upon the sources, they can be catagorized as autologous stem cell and allogeneic stem cell. Autologous stem cell refers as the cells collected from patient's own body and allogeneic stem cell referes as cells harvested from donor's body. The functions and uses of these cells depends on their sources.

Question: What are the sources of stem cells?

Stem cells are harvested from different sources of human body such as bone marrow aspirate, adipose tissue, umbilical cord and blood. Depending upon the sources, they can be catagorized as autologous stem cell and allogeneic stem cell. Autologous stem cell refers as the cells collected from patient's own body and allogeneic stem cell referes as cells harvested from donor's body. The functions and uses of these cells depends on their sources.

Question: Which diseases can be treated with stem cell?

Stem cells are most demanded for it's use in chronic and degenerative diseases. When conventional treatment remains ineffective, stem cell treatment paves a new path there. This treatment is currently used for various degenerative neurological disorders, musculoskeletal conditions, chronic diseases such as liver cirrhosis, kidney failure, metabolic disorders, autoimmune disorders, respiratory diseases, early aging, sexual dysfunction etc.

Question: Question: What are the benefits of stem cell treatment?

Easy procedure, Non-invasive procedure, No Adverse effect, Surgery free treatment, Efficient healing and Long-lasting result

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