How Hypoxic Culture Improves Stem Cell Therapy

Cell‐based regenerative therapies, based on in vitro propagation of stem cells, offer tremendous hope to many individuals suffering from degenerative diseases that were previously deemed untreatable. Due to the self‐renewal capacity, multilineage potential, and immunosuppressive property, mesenchymal stem cells (MSCs) are considered as an attractive source of stem cells for regenerative therapies. However, poor growth kinetics, early senescence, and genetic instability during in vitro expansion and poor engraftment after transplantation are considered to be among the major disadvantages of MSC‐based regenerative therapies. A number of complex inter‐ and intracellular interactive signaling systems control growth, multiplication, and differentiation of MSCs in their niche.